基本信息
姓名：杨政敏
职称：教授
专业：药物化学
研究方向：有机光敏剂合成、诊疗一体化荧光探针、天然药物化学
开设课程：天然药物化学、药物分析
全职工作单位：黔南州中医医院
电子邮箱：251059207@qq.com
个人简介
杨政敏，教授，理学博士，硕士研究生导师。长期从事药物化学、化学生物学和有机荧光探针方面的研究，贵州省科技厅和广西区科技厅专家库专家。近5年以第一作者和通讯作者，在European journal of medicinal chemistry、ACS Sensors、Chemical Communications、Materials Today Chemistry、Bioorganic Chemistry、Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy、等一、二区SCI期刊上发表论文12篇，SCI论文被正面引用300多次。以第一作者和通讯作者在中文核心期刊发表5篇。主持完成贵州省自然科学基金项目（[2020]1Y1052）；博士科研启动基金项目（QNYZ2021001）。参与完成国家自然科学基金（81860317），贵州省科技支撑项目（20192821）。目前主持广西师范大学省部共建国家重点实验室开放基金项目（CMEMR2024-B17）。
科研项目
基于“开-关”型近红外荧光染料构建单胺氧化酶荧光探针及其应用研究，贵州省自然科学基金项目，项目编号：[2020]1Y1052, 2020.03-2023.03, 10万元,已结题，主持；
单胺氧化酶A激活的近红外荧光探针用于光动力和光热治疗肿瘤，贵州省卫生健康委员会基金，项目编号：zwkj2021-453，1万元；已结题，主持；
近红外亮氨酸氨肽酶激活光敏剂的构建及抗肿瘤活性研究，广西师范大学省部共建药用资源化学与药物分子工程国家重点实验室开放基金，项目编号：CMEMR2024-B17，2024.07-2026.07，3万元，在研，主持；
诊疗一体化小分子荧光探针的应用与开发团队，黔南医专创新团队项目，项目编号：QNYZ2023001，2023.07-2026.07，10万元，在研，主持；
检测肿瘤蛋白标志物试剂盒的开发和诊疗一体化应用，黔南医专揭榜挂帅项目，项目编号：QNYZ2025005，2025.07-2028.07，10万元，在研，主持；
6.量子点/配体杂化型荧光传感器设计及在生物医学检测中应用研究，贵州省科技支撑计划，项目编号：20192821，2019.01-2022.12，40万元，已结题，参与；
7.HCR介导的核酸功能化碳点/氧化石墨烯荧光探针用于miRNA超灵敏检测及肿瘤细胞筛选，国家自然科学基金，项目编号：81860317，2019.01-2022.12，35万元，已结题，参与。
代表性论文
[1] Jiman He,Zhengmin Yang*, Cunji Gao, Zhiwei Ouyang, Bingying Cao, Yaling Rao, Liangliang Xiao, Shulin Zhao, Jiangke Qin*, Design and synthesis of fluorescent probes specific for Pantetheinase and their application in bioimaging,Analyst,2026, 10.1039/d5an00338e. (二区SCI, IF: 3.3)
[2]Zhengmin Yang; Tiantian Zhong; Bingying Cao; Dejun Liao; Xianyun Hu; Shulin Zhao; Jiangke Qin*; Monoamine oxidase A probe synthesis and fluorescence imaging in cells and zebrafish based on AIE mechanism,Materials Today Chemistry2024, 35: 101890. (二区SCI, IF: 7.3)
[3]Zhengmin Yang; Tiantian Zhong; Qingyuan Mo; Jiman He; Jia Chong; Xianyun Hu; Shulin Zhao;Jiangke Qin*; Monoamine oxidase B activatable red fluorescence probe for bioimaging in cells and zebrafish,Bioorganic Chemistry2024, 145: 107156 (小类一区SCI, IF: 5.1)
[4]Zhengmin Yang, Qingke Jiang, Tiantian Zhong, Xianyun Hu, Bingying Cao, Zhongyao Han, Shulin Zhao, Jiangke Qin*, Large Stokes Shift and Near-infrared Fluorescent Probe for Bioimaging and Evaluating the HClO in an Rheumatoid Arthritis Mouse Model,Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2024, 319, 124547(二区SCI, IF: 4.4)
[5]Qingyuan Mo, Tiantian Zhong, Bingying Cao, Zhongyao Han, Xianyun Hu, Shulin Zhao, Xiaoyu Wei,Zhengmin Yang*, Jiangke Qin*,Dihydroxanthene-based monoamine oxidase A-activated photosensitizers for photodynamic/photothermal therapy of tumors[J].European journal of medicinal chemistry2024,272,116474.(一区SCI, IF: 6.7;通讯作者)
[6]Zheng-Min Yang, Qing-Yuan Mo, Ji-Man He, Dong-Liang Mo, Jun Li*, Hua Chen, Shu-Lin Zhao, Jiang-Ke Qin*, Mitochondrial-targeted and Near-infrared Fluorescent Probe for Bioimaging and Evaluating Monoamine Oxidase A Activity in Hepatic Fibrosis[J].ACS Sensors2020,5, 943-951. (一区SCI, IF: 8.9)
[7] Rongjun Liu,Zhengmin Yang, Liangliang Zhang*, Jingjin Zhao, Cheng Hou, Shulin Zhao*, A near infrared dye-coated silver nanoparticle/carbon dot nanocomposite for targeted tumor imaging and enhanced photodynamic therapy[J].Nanoscale Advances2020, 2, 489-494. (三区SCI IF: 4.7)
[8] Wenxiu Li, Simin Zhou, Liangliang Zhang*,Zhengmin Yang, Hua Chen, Wenqiang Chen*, Jiangke Qin, Xingcan Shen, Shulin Zhao. A red emitting fluorescent probe for sensitively monitoring hydrogen polysulfides in living cells and zebrafish[J].Sensors & Actuators: B. Chemical2019, 284, 30-35. (一区SCI IF: 7.1)
[9] Chaobang Zhang, Rongkang Gao, Liangliang Zhang, Chengbo Liu*,Zhengmin Yang, Shulin Zhao*, Design and Synthesis of a Ratiometric Photoacoustic Probe for In Situ Imaging of Zinc Ions in Deep Tissue In Vivo[J].Anal. Chem.2020, 92, 6382–6390. (一区SCI IF: 6.785)
[10] Chaobang Zhang, Zhidong Qiu, Liangliang Zhang*, Qiufang Pang,Zhengmin Yang, Jiang-Ke Qin, Hong Liang, Shulin Zhao*, Design and synthesis of a ratiometric photoacoustic imaging probe activated by selenol for visual monitoring of pathological progression of autoimmune hepatitis[J].Chem. Sci., 2021,12, 4883-4888 (一区SCI IF: 9.346)
