人才培养

基本信息

姓名：张健

职称：副教授

专业：药理学

研究方向：中医药抗骨质疏松机制研究

开设课程：比较医学、毒理学基础、实验动物学、实验动物学专业英语、生物医药类英文科技论文阅读与写作

全职工作单位：贵州中医药大学

电子邮箱：zhangjian075@gzy.edu.cn

个人简介

张健，男，副教授，博士，硕士研究生导师，国家自然科学基金函评专家，中国细胞生物学学会会员，实验动物学学会会员。2016年博士毕业于西北工业大学航空宇航与科学技术专业空间生物学研究方向。2016年博士毕业后，在苏州大学放射医学与辐射防护国家重点实验室开展博士后研究，研究方向为电离辐射下的骨质流失机制及防护研究。2018年底博士后出站，入职贵州中医药大学，从事中医药抗骨质疏松机制研究。工作以来，获得国家自然科学基金项目3项（82360176、82060168、31600674）、贵州省科技厅基础研究计划（黔科合基础-ZK[2021]一般398）、博士后科学基金（2017M610352）、贵州省卫生健康委科学技术基金（gzwjkj2019-1-226）等项目资助，以第一或通讯作者在多个国际权威期刊杂志发表SCI论文10余篇，具有丰富的药理学及骨生物学研究经验，取得了良好的科研成果。

科研项目

1.贵州省卫生健康高质量发展医学科研联合基金项目，2024GZYXKYJJXM0132，2025.02-2028.02，主持

2.国家自然科学基金地区项目，82360176，2024.01-2027.12，主持

3.国家自然科学基金地区项目，82060168，2021.01-2024.12，主持

4.贵州省科技厅，黔科合基础-ZK[2021]一般398，2021.04-2024.03，主持

5.国家自然科学基金青年项目，31600674，2017.01-2019.12，主持

代表性论文

1.Jian Zhang*, Lingyan Zhang. Building a sustainable framework for laboratory animal welfare and ethics education: challenges and reform strategies.Frontiers in Veterinary Science. 2025.12:1684284.

1. Jian Zhang*, Lingyan Zhang, Gang Yao, Hai Zhao, Penghai Qiao, Shuguang Wu. lncRNA-Gm5532 regulates osteoclast differentiation through miR-125a-3p/TRAF6 axis. Acta Biochimica et Biophysica Sinica. 2024. 56(1): 54-61.

2. Jian Zhang*#, Lingyan Zhang#, Gang Yao, Hai Zhao, Shuguang Wu. NRF2 is essential for iron‑overload stimulated osteoclast differentiation through regulation of redox and iron homeostasis. Cell Biology and Toxicology. 2023. 39(6): 3305-3321.

3. Yuanqing Jin, Shuguang Wu, Lingyan Zhang, Gang Yao, Hai Zhao, Penghai Qiao, Jian Zhang*. Artesunate inhibits osteoclast differentiation by inducing ferroptosis and prevents iron overload-induced bone loss. Basic & Clinic Pharmacology &Toxicology. 2023. 132: 144-153.

4. Lingyan Zhang, Jian Zhang*, Yuanqing Jin, Gang Yao, Hai Zhao, Penghai Qiao, Shuguang Wu. Nrf2 is a potential modulator for orchestrating iron homeostasis and redox balance in cancer cells. Frontiers in Cell and Developmental Biology. 2021. 9: 728172

5. Jian Zhang*, Hai Zhao, Gang Yao,Penghai Qiao, Longfei Li, Shuguang Wu. Therapeutic potential of iron chelators on osteoporosis and their cellular mechanisms. Biomedicine & Pharmacotherapy. 2021. 137: 111380

6. Jian Zhang*. The osteoprotective effects of artemisinin compounds and the possible mechanisms associated with intracellular iron: a review of in vivo and in vitro studies. Environmental Toxicology and Pharmacology. 2020. 76: 103358

7. Jian Zhang*, Penghai Qiao, Gang Yao, Hai Zhao, Yanjun Wu, Shuguang Wu. Ionizing radiation exacerbates the bone loss induced by iron overload in mice. Biological Trace Element Research. 2020, 196: 502-511

8. Jian Zhang*, Wentao Hu, Chong Ding, Gang Yao, Hai Zhao, Shuguang Wu. Deferoxamine inhibits iron-uptake stimulated osteoclast differentiation by suppressing electron transport chain and MAPKs signaling. Toxicology Letters. 2019, 313: 50-59.

9. Jian Zhang#, Lijun Zheng#, Ziyang Wang, Hailong Pei, Wentao Hu, Jing Nie, Peng Shang, Bingyan Li, Tom K. Hei*, Guangming Zhou*. Lowering iron level protects against bone loss in focally irradiated and contralateral femurs through distinct mechanisms. Bone. 2019, 120: 50-60.